Eurocine Vaccines today announced good safety and tolerability in older adults, in the second clinical phase I/II study including their quadrivalent influenza vaccine candidate. Immunose™ FLU is a novel nose drop formulation based on the company’s technology Endocine™ and inactivated split influenza antigens.

– I am very happy that we have once again confirmed good safety, this time in older adults, a population in need of better influenza vaccines. Now we look forward to the immunological results, which are expected in October, says Dr. Anna-Karin Maltais, CSO, Vice President R&D.

The study was conducted during the influenza season 2017/2018 with the purpose to evaluate safety and tolerability, as well as serological and mucosal immune responses to four influenza strains in older adults aged 50-75. A total of 298 subjects, with a mean age of 63 years, were divided into seven treatment groups and the study was conducted at five locations throughout Sweden. The compliance was high, with 99% of the subjects completing the clinical part of the study.

No serious adverse event was reported in the Immunose™ FLU groups. The reported adverse events were mostly mild or moderate. A tolerability evaluation measuring discomfort at the administration site showed mild and transient experiences, lasting less than two hours.

With this study, the safety database has expanded to a total of over 400 subjects for the platform technology Endocine™.

The data put us exactly where we want to be for our further development and in our hunt for the next vaccine project, says Dr. Hans Arwidsson, CEO.

For more details, please visit:
https://clinicaltrials.gov

This information is information that Eurocine Vaccines AB (publ) is obliged to make public pursuant to the EU Market Abuse Regulation (no. 596/2014). The information was submitted for publication, through the agency of the contact person set out above, on August 8th, 2018.